Investigation of blood levels of vitamin D in women with breast cancer and its correlation with prognostic markers

Introduction: Breast cancer is the most common cancer among women and the second cause of death after lung cancer. Several studies have been conducted to find the better prognosis in patients with breast cancer, which have associated with contradictory results. Current study was done in order to find the relationship between vitamin D and tumor markers and to improve the prognosis of breast cancer patients Materials and Methods: In this cross-sectional descriptive-analytic study, 105 patients referred to oncology clinics of Fatemieh and Kowsar hospitals in Semnan city (Iran) from 2012 to 2016 years were evaluated. Levels of vitamin D, prognostic markers of breast cancer including estrogen, progesterone, HER-2, P53 and Cyclin D1 receptors and menopause status of patients and also relationship between them were assessed. Results: The results showed that mean of vitamin D was optimal (22.8±9.48) and the maximum frequency of markers related to ER and PR and the minimum one related to HER2. There was not statistically significant relationships between markers and level of vitamin D, but menopausal status and the level of vitamin D had a significant relationship, so that the level of vitamin D in menopausal women was higher than non-menopausal women (p<0.05). Also, association between the status of tumor markers and menopausal status was not found. Conclusion: The level of vitamin D in women with breast cancer was in an adequate level and the level of this vitamin was not associated with prognostic markers. Further studies are suggested in this regard Keywords: Breast Cancer, Tumor Marker, Vitamin D, Menopause.