O-021 Long-term prognosis for live birth in women with recurrent miscarriage: a descriptive follow up study of a cohort of 987 women

Results: Of the women fulfilling inclusion criteria, 33.3% (95% CI: 30.3 to 36.3) had not achieved a subsequent live birth five years after first consultation decreasing to 28.9% (25.9 to 32.1) 20 years after first consultation. At attained age 30, 40 and 49 the average number of children born by women in the cohort was 1.23, 1.54 and 1.47 children, respectively. In the general population a comparable measure was 1.13, 1.70 and 1.71 children per woman, respectively. Women in the RM cohort were, compared with women in the general population, 3.84 (3.44 to 4.28) times more likely to give birth during the first year after first consultation. This figure declined towards the level of the general popula tion over the following five years. Conclusions: Approximately two thirds of women with RM referred to a tertiary miscarriage clinic succeed in having at least one live birth after referral. However, the average number of children born by women with RM seems low taking into account the strong wish for a child of these women. Fecundity rates are markedly increased during the first year after referral, which presumably is primarily a result of differences in pregnancy attempts in women with RM and women of the general population (the women are encouraged to become pregnant when monitored at a dedicated RM clinic) but also due to an increased live birth rate per pregnancy of women with RM (through relevant treatment of established risk factors). Further research into the specific risk factor profile of the subgroup of women with RM without a subsequent live birth is needed as well as comparison of fecundity rates in women with RM with a population of women with an equally strong wish for a child.