Optimal hypothermia to protect arrested heart in vivo (1104.29)

Objective: To determine the optimal protective hypothermia in arrested hearts.Methods: Pig hearts in vivo infused with cardiopulmonary bypass; Myocardial velocity (V max) and left ventricular dP/dt max (dP/dt max )was used to present contractility A heart arrested patient treated with 32 degree C cooling protocol.(Kupchik NL:Crit Care Med 37[Suppll]S279,2009).Results: 17 hearts arrested 60 min with 29-35°C. At 60 min of reperfusion (20 min of off-pump), the recovery of Vmax and dP/dtmax show sigmoid curves that consist two plateaus: a good recovery plateau at 29 -30°C and a poor recovery plateau at 34 -35°C (p<0.05). There exists a point of inflection at the right side of the high recovery plateau. That point should be the optimal protective hypothermia (Figure 1). One of the authors suffered from a sudden cardiac arrest more than 6 min. He was treated with hypothermic rescue (32°C ) resulted a full recovery. Conclusion: Around 30.5°C is an optimal protective hypothermia for arrested heart. $$graphic_2554...