Experimental model of induction in the rat of rapidly developing biliary cirrhosis in peripartal nodular cirrhosis

: The treatment with CCl4 and progesterone subsequent the common biliary duct ligature induced, in the rat, after 4-5 weeks, a cirrhotic picture characterized by an early and strong biliary epithelium proliferation followed by a perilobular fibrosis with a concentric sclerosis as in true perilobular cirrhosis.