PROGNOSTIC FACTORS AND OUTCOMES OF POSTOPERATIVE RADIOTHERAPY FOR MALIGNANT GLIOMAS: A SINGLE-INSTITUTION EXPERIENCE

Purpose : To investigate the prognostic factors and treatment outcomes of patients with malignant gliomas treated with postoperative radiotherapy. Material and Methods : We retrospectively reviewed the medical records of patients with malignant gliomas who received postoperative radiotherapy in our department between April 2007 and October 2014. Clinical characteristics, surgical resection status, and image findings of these patients were reviewed and analyzed. The primary endpoint was overall survival (OS). Results : Thirty-four patients were included in the study. Thirteen patients (38%) were diagnosed with anaplastic astrocytoma (AA) and 21 patients (62%) with glioblastoma (GBM). The median follow-up time was 14 months (range: 4–46 months). The median OS for all patients was 14.3 months (range: 3.8–45.7 months). The median OS of patients with AA and those with GBM were 15.2 and 12.3 months, respectively (p = 0.0355). In patients with GBM, group 1 (tumor resected more than 50%) had better OS than group 2 (tumor resected less than 50%, p = 0.0225). Conclusions : Our results showed similar OS to published articles. Surgical resection status was demonstrated to be an important prognostic factor for OS in patients with GBM.