Construction of fluoride-containing PLLA nanofiber scaffold for Bone Regeneration

In this study, a novel material, fluoride-containing Poly (L-lactic acid) (PLLA) nanofibre scaffold was successfully constructed through electrospinning process. Scanning electron microscopy (SEM) image showed that the morphology of the fibres was uniform and smooth, and the average diameter of the fibres was about 300 nm. Transmission electron microscopy (TEM) proved that a lot of calcium fluoride (CaF2) nanoparticles with an average diameter of about 50 nm were well dispersed in the PLLA fibre matrix. Fluoride is one of the few inorganic ions which are able to stimulate osteoblasts (OB). This novel material seems to be a promising scaffold for bone tissue engineering.