FLAVONOIDS AND BIOACTIVITY OF SAGERETIA GRACILIS

From the rhizomes ofSageretia gracilissix flavonoids were isolated and determined as maesopsin (1), maesopsin-6-O-β-D-glucopyranoside (2), 5,7,4′-trihydroxy dihydroflavonol (3), 5,7,4′-trihydroxy dihydroflavonol-3-O-α-L-arabinofuranoside (4), 5,7,4′-trihydroxy dihydroflavonol-3-O-α-L-rhamnopyranoside (5), 5,7,4′-trihydroxy flavonol (6) together with octadecoic acid, methyl triacontanoic acid and daucosterol based on spetral data, in which compound 4 is a new compound.The EtOH extracts, H 2O extracts, petroleum ether fractions, EtOAc fractions, n-butanol fractions, compound 1, 5 and 6 were tested on PEPT, YNG, CDC25, CAT-B, CA-II and PAI bioassays respectively for finding some samples with anti-bacterium, anti-fungus, anti-cancer, anti-osteoporosis, anti-thrombus activities.The results indicated that only the n-butanol fractions and H 2O extracts showed anti-bacterium and anti-fungus activities with the IC 50 of 74.9 and 13.8 μg/ml, respectively.