Does treatment with beta-adrenergic blocking agents cause a decrease in beta2-adrenoceptor affinity?

The effect of β-adrenoceptor antagonists (BAAs) differing in lipophilicity and partial agonist activity (PAA), and a full agonist, on the dissociation constant for [125I]-(−)- iodocyanopindolol binding to β2-adrenoceptors (KD) has been investigated.