Association of rs12204590 polymorphism with the development of stroke in hypertensive patients

The stroke is one of the most serious complications of arterial hypertension (HTN). Genetic markers of the disease can be used to improve the risk stratification. According to the literature data of single nucleotide polymorphism (SNP) rs12204590 (T > A) is a new potential genetic marker for stroke, however, in published studies, cardiovascular pathology preceding stroke was not assessed. Objective. To study the association of SNP rs12204590 (T > A) with the development of stroke in patients of the East Siberian population with HTN and without HTN. Design and methods. The study involved 260 patients with stroke (age 57,0 [51,0-62,0] years) and 272 patients of the control group (age 55,0 [51,0-62,0] years). Among stroke survivors, there were 157 men and 103 women. The control group included 170 men and 102 women. 249 patients ofthe main group and 177 patients of the control group had HTN. The following risk factors for the development of stroke were present in the main group: paroxysmal supraventricular tachycardias, dyslipidemia, atherosclerosis of the brachiocephalic arteries, disorders of the hemostasis system. All participants underwent clinical, instrumental and molecular genetic research. Statistical analysis was carried out using the programs Statistica for Windows 7.0, Excel and SPSS 22. Results. The association of TA genotype SNP rs 122045 90 (T > A) with the development of stroke was confirmed in the main group, as well as in the subgroup of HTN patients who had stroke. An association of the AA genotype with stroke was found in males. Associations of the studied polymorphism with the risk factors for stroke were not identified. Conclusions. The TA genotype rs12204590 (T > A) reduces the risk of acute stroke compared to the genotypes TT and AA, which is also observed in HTN patients. The AA SNP genotype rs12204590 (T > A) increases the risk of developing stroke in males.