Improved method for stability of ageing comprising thirosinase inhibitor activity

This pharmaceutical is composed of 0.1-30wt% the pharmceutical components 8-99.68wt% hydrophobic tackifier 0.1-30wt%, skin absorption enhancer stabilizer solubilizer 0.1-20wt%, 0.01-2wt%, and 0.1-10wt% side effect reducer. The above pharmaceutical component with thirosinase inhibitor activity is one or more compounds selected from ascorbic acid and its deriv., kojic acid and its deriv., glycosamines, hydroquinone and its deriv., compounds with -SH group and butylhydroxytoluene and butylhydroxyanisone; and hydrophobic tackifier. This pharmaceutical is prepared to matrix or reservoir type structure and percutaneous absorption type. The above tackifier is acrylic polymer.