Bipyridyl derivatives useful for treating diseases induced kinases
2011
Compound of formula (I) ** ** Formula where: W1, W2, W3 indicate CR3, or W1, W2 indicate CR3, and W3 indicates N, R1 denotes phenyl which may be independently substituted by at least one substituent selected from the group consisting of Y, Hal, CN, CF3 or OY, R 2 denotes Ar, Het1, Het2, NY-Het1 or NY-Het2, each of which may be substituted independently by R4, R3 denotes H, R4 denotes Hal, A, - (CYY) n OY, - (CYY) n-NYY, (CYY) n-Het³ (CYY) nO-Het³, SY, NO2, CF3, CN, COOY, - CO-NYY, - NY-COA, -NY-SO 2, -SO2-NYY, S (O) mA, -CO-Het³, -O (CYY) n-NYY, -O (CYY) n-Het³, -NHCOOA, -NH-CO -NYY, -NH-COO- (CYY) n-NYY, -NH-COO- (CYY) n-Het³, -NH-CO-NH- (CYY) n-NYY, -NHCO- NH (CYY) n- Het³, -OCO-NH- (CYY) n-NYY, -OCO-NH- (CYY) n-Het³, CHO, COA,> = S,> = NY and> = O, Y denotes H or A, A denotes alkyl branched or unbranched alkyl having 1, 2, 3, 4, 5, 6, 7, 8, 9 or 10 C atoms, in which 1, 2, 3, 4, 5, 6 or 7 atoms H they may be substituted independently by Hal and / or e l one or two CH2 groups may be replaced independently by O, S, SO, SO2, a -CY> = CY- and / or a group -CoC- group, Ar denotes a monocyclic or bicyclic saturated, unsaturated or aromatic ring having 5, 6, 7, 8, 9 or 10 C atoms, Het1 denotes a mono- heterocycle, bi- or tricyclic saturated or unsaturated ring having 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 carbon atoms and 1, 2, 3, 4 or 5 atoms N, O and / or S, Het2 indicates a mono heteroaryl, bi- or tricyclic It is having 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19 or 20 carbon atoms and 1, 2, 3, 4 or 5 carbon atoms of N, O and / or S, Het 3 denotes a mono heterocycle, bi- or tricyclic saturated or unsaturated ring having 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16 , 17, 18, 19 or 20 carbon atoms and 1, 2, 3, 4 or 5 atoms N, O and / or S, which may be substituted independently by at least one substituent selected from the group Hal , A, - (CYY) n OY, - (CYY) n-NYY, S And, NO2, CN, CF3, COOY, -CO-NYY, -NY-COA, -NY-SO 2, -SO2-NYY, S (O) mA, -NH-COOA, -NH-CO-NYY, CHO, COA,> = S,> = NY and> = O, Hal denotes F, Cl, Br or I, m denotes 0, 1 or 2, n denotes 0, 1, 2, 3 or 4, and salts, solvates, tautomers and stereoisomers physiologically acceptable thereof, including mixtures thereof in all proportions.
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