Developmental expression of SNAP-25 protein in the rat striatum and cerebral cortex
2004
The developmental changes of 25-kDa synaptosomal-associated protein (SNAP-25)
expression in the rat striatum and cerebral cortex were examined using Western-
blotting and densitometric scanning of immunoblots. Analysis of the striatum
extracts from postnatal day 0 (P0) to postnatal day 120 (P120) demonstrated
that SNAP-25 is poorly expressed until P14. From this point the expression
level gradually increases to reach a maximum on P60 and then decreases. The
pattern of SNAP-25 expression in the rat cerebral cortex is different. Two peaks
are observed, the first on P10 and the second on P60, after which the expression
level decreases. These results appear to confirm the role of SNAP-25 protein
in axon outgrowth and synaptogenesis in the nervous system.
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