血栓素B2、6-酮-前列腺素F1α与牙周病和冠心病关系的研究

AIM: To explore the relationship between periodontitis and coronary heart diseases (CHD) by comparig the levels of TXB2 and 6-K-PGF1α in serum among four groups. METHODS: 40 subjects were divided into 4 groups according to the diagnostic angiography and periodontal examination as group CP, group C, group P and group HP. Group HC was made up of 10 CHD patients with moderate to advanced periodontitis.10 CHD patients without periodontitis were as group C. Group P was made up of 10 patients suffering moderate to advanced periodontitis. Group H was 10 healthy volunteers. The general information about periodontal status of all the subjects were recorded and blood samples were withdrawed. The level of TXB2 and 6-K-PGF1α were detected by radioimmunoassay. RESULTS: The general information including age, sex, body mass index (BMI) and smoking history had no significant differences (p＞0.05), but the hypertension history had significant differences among four groups (p＜0.05). One way analysis of variance showed that the level of TXB2 and 6-K-PGF1α in serum from the patients of group CP､C and P were higher than the group H (P＜0.05). CONCLUSION: TXB2 and 6-K-PGF1α may be important mediators in the initiation and progression of coronary heart disease and periodontitis and contribute correlation between CHD and periodontal diseases.