Metabolic fingerprint of serum in first trimester of healthy pregnancy permits the prediction of macrosomia

INTRODUCTION: Macrosomia is associated with pregnancy complications and is suggested to predict child’s and mother’s health. High birth weight (>4,000 g) has been associated to the risk of several major chronic diseases in future life including diabetes, cardiovascular disease or cancer. Additionally delivery of a large baby carries a risk of perinatal complications. The aim of this study was to obtain serum fingerprints of healthy pregnant women to identify early biomarkers of macrosomia and to understand the mechanisms leading to abnormal fetal growth not related to mother’s BMI or presence of GDM.