Vascular-targeted photodynamic of prostate cancer phase with Tookad for recurrent prostate cancer following radiation therapy: initial clinical studies
2007
We report on the first clinical application of vascular-targeted photodynamic therapy using a bacteriopheophorbide
derivative, Tookad, in patients with localized prostate cancer following external beam radiation therapy. Patients
received either escalating intravenous drug doses at a fixed light dose or escalated light doses at the highest
photosensitizer dose. Two cylindrically diffusing fibers were placed transperineally in the prostate, along with light
monitoring fibers in the prostate, urethra and rectum. Treatment response was assessed with 7-day gadolinium-enhanced
T1-weighted MRI and 6-month biopsy. Lesion formation was strongly drug and light dose-dependent, with an apparent
threshold response. Early biochemical and MRI responses support the clinical potential of TOOKAD-PDT to treat
locally-recurrent prostate cancer.
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