Preparation and Characterization of Anti-Paralytic Shellfish Poison Poly- and Monoclonal Antibodies for Development of Identification and Prophylaxis/Therapy Techniques

Abstract : The development of polyclonal antibodies having good cross-reactivity against the entire family of the paralytic shellfish posions has been the focus of this research effort. One approach to this problem is the design of small hapten molecules which express the epitopes common to all the PSP toxins. Since the ganidinium ring systems are integral parts of all of the toxin molecules, synthetic routes to both the five- and the six-membered ring systems have been