Hepatocyte free cholesterol lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent

Lay T. Gan,Derrick M. Van Rooyen,Mark E. Koina,Robert S. McCuskey,Narcissus Teoh,Geoffrey C. Farrell

Hepatocyte free cholesterol lipotoxicity results from JNK1-mediated mitochondrial injury and is HMGB1 and TLR4-dependent

2014

Lay T. Gan
Derrick M. Van Rooyen
Mark E. Koina
Robert S. McCuskey
Narcissus Teoh
Geoffrey C. Farrell

This study was supported by the Australian National Health and Medical Research Council (NHMRC) project grants APP418101 and APP585411, and the NHMRC scholarship 1017886.

Keywords:

Virology
Lipotoxicity
HMGB1
Oxidized Glutathione
Hepatocyte
TLR4
Free cholesterol
Immunology
Mitochondrial permeability transition pore
Endocrinology
Internal medicine
Medicine
national health
Mitochondrion

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