Efficient Conversion of Glucose into Fructose via Extraction-Assisted Isomerization Catalyzed by Endogenous Polyamine Spermine in the Aqueous Phase

In the present study, natural polyamine spermine is demonstrated as a potential basic catalyst for glucose-to-fructose isomerization. For instance, spermine achieves a decent fructose yield (30% wt) and selectivity (74%) during the single-step aqueous phase isomerization under the modest operating conditions (100 °C for 15 min). In addition to the expected reaction byproduct monosugar mannose, spermine also assists in the synthesis of rare and important monosugar, that is, psicose up to 4% wt. Psicose is a zero calorie rare sugar, exhibits a low caloric value, and possesses anti-adipogenic property. A comparative study involving other polyamines concluded that the presence of 20 amines tends to exhibit the most significant impact in improving the target product yield by releasing a higher number of OH– ions, which are responsible for isomerization through the formation of an enediol anion. An attempt was made to further improve the fructose yield through the addition of neutral salts, but it promoted a me...