CORRECTION OF TESTES AGE CHANGES RATS THROUGH GADOLINIUM ORTOVANADAT IN NANOFORM

During this period, the greatest amount of obtained nanomaterials based on transition of rare earth metals, some of which have significant biological activity. In particular, vanadium compounds have expressive insulin-mimetic action and gadolinium orthovanadate (GdVO4) in nanoform capable in aging laboratory animals inhibit the development of age-related changes, namely a gradual increase (in the physiological range) age glucose level, body weight, reduction of the nervous system reactions and increases the sperm concentration. Given the urgency of anti-aging drug development focus, found a positive effect on spermatogenesis and the lack of information on the effect of this compound on the functional state of the gonads, studied morphofunctional status and endocrine function of the testes in older (18–18.5 months) male rats in long-term (70 days) using nanoparticles (NP) based on GdVO4 dose of 0.33 mg/kg body weight. It was establish the positive effect on bass GdVO4 testicular hormonal function, as evidenced by an increase in serum testosterone (56.3 % at 60 days compared to the injection on the 20th day). It was not found gonadotoxical impact bass GdVO4, as in the seminiferous tubules of the main animals present full pool of germ cells spermatogenesis. Morphometric parameters of glands histological structure indicate the activation of spermatogenesis, which may be due to increasing activity of hormone-producing testes of animals after chronic use NPs GdVO4.