Platelet reactivity in patients with atrial fibrillation

We read the article entitled ‘Gender and tachycardia: independent modulation of platelet reactivity in patients with atrial fibrillation’ with great interest. In this article Procter, et al.[1] reported that gender and heart rate are independent determinants of platelet function in patients with acute atrial fibrillation (AF). The authors pointed that female sex correlated with impaired nitric oxide (NO) responses independent of platelet aggregability and admission heart rate. However, we have some suggestions about this study: there was no control group and all patients included were > 45 years old; also, mean platelet volume (MPV) is not investigated in study group.