Evaluation of dihydropyridine calcium antagonist effects on the stressbioindicator organism Saccharomyces cerevisiae

Nifedipine is the subject of several studies since their introduction into clinical medicine in 1975. Some of them found it as a protective solution against stress increase, but others works demonstrate that can be a stress source. That’s why in this present paper we want to put in evidence the effect which has this molecule on bioindicator stress: the yeast Saccharomyces cerevisiae. These effects have been studied by measuring the cell proliferation, respiratory activity and the levels of some biomarkers (CAT, MDA). The results obtained show a significant inhibition on cell proliferation of yeast and respiratory metabolism. We noted also a significant/high significant increase in all studied biomarkers following treatment with a dose-response manner