Synthesis of Flurbiprofen Axetil

OBJECTIVE To synthesize Flurbiprofen Axetil.METHODS Tetrahydronaphthalene was treated with bromine to produce hydrogen bromide.The hydrogen bromide was dissolved in anhydrous acetic acid,and this solution was reacted with vinyl acetate to prepare 1-(acetoxy)ethyl bromide.Flurbiprofen Axetil was synthesized by esterfication of Flurbiprofen with 1-(acetoxy)ethyl bromide.RESULTS and CONCLUSION Raw materials are easily obtained.Synthesis route is simple and suitable for development and manufacture.