Single-Dose Intravenous Flurbiprofen Administration Increases Blood Pressure Under General Anesthesia In Normotensive Patients

We studied whether blood pressure elevation is influenced by intravenous single-dose administration of flurbiprofen during general anesthesia. Twenty female patients who underwent lower abdominal laparotomy under general anesthesia were divided into two groups. Both groups received anesthesia with nitrous dioxide, sevoflurane, and pentazocine. The flurbiprofen group (n=10) received 50 mg flurbiprofen intravenously 10 minutes after the start of the surgery. The control group (n=10) received 50 mg flurbiprofen at the end of the examination. Blood pressure was assessed before administration (0 minute as baseline) and after administration (15, 30 and 60 minutes). Systolic blood pressures inceased after 60 minutes in the flurbiprofen group (fluctuation ratio from baseline: 1.28±0.06, mean±SEM) compared with that in the control group (1.07±0.04, p <0.05) and with baseline at 15, 30, and 60 minutes (1.17±0.05, 1.17±0.05, and 1.28±0.06, respectively, p <0.05).