Клинико-патогенетические аспекты антиоксидантной терапии при черепно-мозговой травме

The traumatic brain injury is the first in the structure of the entire neurosurgical pathology and is the most common cause of death and disability in adults. Cerebral hypoxia and local ischemia is the leading pathogenetic syndromes of the brain injury. Activation of lipid peroxidation and conjugate reduction of antioxidant activity of the brain, cerebrospinal fluid, blood is a direct consequence of hypoxia and ischemia. In this paper we study the dynamics of the cerebral hypoxia in cerebrospinal fluid in patients with severe traumatic brain injury on the background of basic therapy and with the additional use of antioxidant drugs. According to the study, from the first day has been a steady increase of all indicators of hypoxia with a maximum increase on the fifth day and stabilization to the tenth day that characterizes the brain damage. Proved, that earlier initiation of antioxidant therapy promotes formation protective adaptive reactions at the level of the cell membranes of the brain cells, that prevents activation of lipid peroxidation and is effective method of preventing secondary hypoxic damage of the brain in traumatic brain injury.