The problem of sodium metabolism in chronic kidney failure

Abstract The endogenous 24-hour-clearance and the sodium excretion during 24 hours in the urine were investigated on 12 healthy persons with chronic nephropathies, 5 patients with condition after acute renal failure and 75 patients with condition after transplantation of a kidney. A correlation between the quantity of urine and the excretion of sodium in 24 hours could be proved in patients with a retention to 884.0 mumol/l creatinine in the serum. Only with further restriction of the renal function a reduction of the sodium excretion during 24 hours below 150 mmol becomes significant. In 16 of 25 patients in the early phase of the again occurring renal function after transplantation the sodium excretion more rapidly improved than the creatinine clearance. In 20 patients with chronic crises of rejection in 15 cases the creatinine clearance and the sodium excretion simultaneously decreased. In one patient the rejection began with a reduction of the sodium excretion.