An exploratory study; the therapeutic effects of premixed activated charcoal–sorbitol administration in patients poisoned with organophosphate pesticide

AbstractObjective. The effects of activated charcoal (AC) mixed with cathartics for gastric decontamination in the management of organophosphate (OP) poisoning remain unknown due to limited clinical evidence. This exploratory study assessed the effectiveness of premixed AC–sorbitol as a treatment for OP poisoning. Materials and methods. This retrospective observational case study included patients who either did not receive AC–sorbitol or received a single dose of AC–sorbitol within 24 h after OP ingestion. The patients were divided into three groups: no AC–sorbitol treatment, patients who received AC–sorbitol within 1 h of OP ingestion, and patients who received AC–sorbitol more than 1 h after OP ingestion. Mortality, the development of respiratory failure, and the duration of mechanical ventilation were used as outcome measurements for effectiveness, whereas aspiration pneumonia and electrolyte imbalance were employed as safety measurements. Result. Among 262 patients with OP poisoning, 198 were include...