Associação da doença hepática gordurosa não-alcoólica e do modelo de avaliação da homeostase de resistência à insulina

Objective: Correlate the values ​​of the Model of Assessment of Insulin Resistance Homeostasis (HOMA-IR) with degrees of non-alcoholic hepatic steatosis. Methods: Clinical and prospective study, approved by the Ethics Committee through protocol 2,314,735 and carried out in the period between October 2017 and July 2018, at a reference center for ultrasonography in Aracaju-SE. Fasting blood glucose and serum insulin were measured for all patients. The following formula was used to calculate HOMA-IR: (fasting blood glucose X basal insulin X 0.0555) / 22.5. Results: Of 114 patients, 7 met the exclusion criteria, with the final sample being 107. The presence of non-alcoholic liver steatosis was found in 90 (84.11%) patients. Of these, 40 corresponded to grade 1; 42 to grade 2 and 8 had grade 3. HOMA-IR was calculated and proved to be directly proportional to the severity of hepatic steatosis. The absence of fatty liver infiltration had an average HOMA-IR of 1.30; 2.23 grade 1; grade 2 of 3.00 and grade 3 of 8.05. Conclusion: HOMA-IR is a non-invasive parameter that can be used to help assess the severity of non-alcoholic hepatic steatosis.