Значение матриксной металлопротеиназы-9 в диагностике фиброза печени у больных хроническими моно- и микст-вирусными гепатитами

The paper studies clinical, biochemical and virological parameters and immunological indicators of liver fibrosis in 120 patients with chronic viral hepatitis of different aetiology (B, C and mixed В+С, В+D, B+C+D). The mixed viral involvement caused more massive changes in the clinical picture of the disease. All the cases were characterized by the decrease in the matrix metalloproteinase-9 content in blood serum. Its deficit correlated with the progression of fibrotic changes in liver. Contrariwise, there was an increase in the protease with inhibitor level. The high indices were detected in case of viral hepatitis B of both monoand mixed infections that could be explained by progressive fibrotic changes and marked cancer-causing potential of this pathogen. The authors indicate the direct dependence between the degree of viral load and degree of liver fibrosis.