The Influence of Sequence Dependence and External Solvents on DNA Conformation

DNA sequence has important biological significance, its effect on groove size affects the expression of protein specific and non-specific binding groove. In liquid environments, different solvents interact with DNA differently. In this chapter, we will focus on the microscopic mechanism of internal bases and external solvents on DNA conformation. In the ordinary water solvent, with the increase of G base content, the DNA structure is transformed by B form—(A-B)—A form. In glycol solvents, DNA maintains B-form configuration, while in ethanol solvent and low activity water solvent, DNA exhibits a shorter and denser A-form.