Role of the Human ST6GalNAc-I and ST6GalNAc-II in the Synthesis of the Cancer-Associated Sialyl-Tn Antigen

Nuno T. Marcos,Sandra Pinho,Catarina Grandela,Andrea Cruz,Bénédicte Samyn-Petit,Anne Harduin-Lepers,Raquel Almeida,Filipe Silva,Vanessa A. Morais,Júlia Costa,Jan Kihlberg,Henrik Clausen,Celso A. Reis

Role of the Human ST6GalNAc-I and ST6GalNAc-II in the Synthesis of the Cancer-Associated Sialyl-Tn Antigen

2004

Nuno T. Marcos
Sandra Pinho
Catarina Grandela
Andrea Cruz
Bénédicte Samyn-Petit
Anne Harduin-Lepers
Raquel Almeida
Filipe Silva
Vanessa A. Morais
Júlia Costa
Jan Kihlberg
Henrik Clausen
Celso A. Reis

The Sialyl-Tn antigen (Neu5Acalpha2-6GaINAc-O-Ser/Thr) is highly expressed in several human carcinomas and is associated with carcinoma aggressiveness and poor prognosis. We characterized two human ...

Keywords:

Ovarian cancer
ST6GalNAc II
Carcinoma
Cancer
Mucin
Antigen
Sialyl Tn antigen
Molecular cloning
Immunology
Molecular biology
Biology
Glycoconjugate
Glycopeptide
Glycoprotein
Cell culture
Tn antigen
Enzyme
Recombinant DNA

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