Synthesis and Structure Activity Relationships of a Series of Penicillin-Derived Pseudosymmetric Inhibitors of HIV-1 Proteinase

David C. Humber,M.J. Bamford,Richard C. Bethell,Nicholas Cammack,Orr Dc,Richard Storer,Gordon G. Weingarten,Paul G. Wyatt

Synthesis and Structure Activity Relationships of a Series of Penicillin-Derived Pseudosymmetric Inhibitors of HIV-1 Proteinase

1994

David C. Humber
M.J. Bamford
Richard C. Bethell
Nicholas Cammack
Orr Dc
Richard Storer
Gordon G. Weingarten
Paul G. Wyatt

The synthesis from penicillin G of a series of potent pseudosymmetric inhibitors 11 a-k of HIV-1 proteinase is described. The 2-pyridyl substituted compounds 11a and 11j showed improved antiviral activity compared to their C2-symmetric counterparts 3 and 4.

Keywords:

Virology
Biochemistry
Enzyme
Virus
Chemical synthesis
Penicillin
Biology
Enzyme inhibitor
Benzylpénicilline
Stereochemistry
human immunodeficiency virus

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