31 Pulmonary hypertension in severe aortic stenosis: prevalence and reversibility with transcatheter aortic valve implant

Introduction We explored the impact of transcatheter aortic valve implantation (TAVI) on pulmonary hypertension (PH) by assessing the prevalence and reversibility of PH in an unselected TAVI cohort. We also identified factors that may predict PH and regression of PH after TAVI. Methods Retrospective analysis of a local TAVI database. 308 consecutive patients underwent TAVI between 2008–13. Pulmonary artery systolic pressure (PASP) was estimated from the velocity of tricuspid regurgitation jet using Bernouille principle; PH was diagnosed if PASP was ≥50mmHg. Simple correlation (Spearman’s rank rS) and regression analyses were used to determine predictors of PH and the change (and 95% confidence interval) in PASP (ΔPASP) after TAVI. Wilcoxon signed-rank Z-test was used to analyse ordinal data. Results 71 (23%) patients had PH, in this group mean PASP before TAVI was 62 ± 6.5mmHg. PASP reduced in 56%, the mean ΔPASP was -12.8mmHg (95% C. I. -9.5 to -16.1, P Conclusion PH is common and usually reversible post TAVI. MR is a significant predictor of PH, the only predictor of regression of PH is reduction in LV end-diastolic function at implantation.