Correlation between Helicobacter pylori infection and serum lipopolysaccharide binding protein in patients with coronary heart disease

Objective To investigate the relationship between Helicobacter pylori (HP) infection and serum lipopolysaccharide binding protein (LBP) in patients with coronary heart disease (CHD). Methods From March 2017 to July 2017, 116 patients who underwent coronary angiography at the Department of Cardiovascular Medicine of Tai′an Central Hospital were included. They were divided into a CHD group (85 cases) and a non-CHD group (31 cases). The 85 CHD patients were further divided into an HP positive group (48 cases) and an HP negative group (37 cases). Double antibody sandwich enzyme-linked immunosorbent assay (ELISA) was used to determine HP and LBP in serum. Homocysteine (HCY), fibrinogen (Fg), high sensitive C reactive protein (hsCRP), triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), and low density lipoprotein cholesterol (VLDL-C) were examined. Patients′ body weight, height, age, sex, history of smoking, history of hypertension, history of CHD, body mass index (BMI), Fg, TG, TC, HDL-C, LDL-C, VLDL-C, HCY, hs-CRP, age, LBP, and HP content were compared by t-tests. The Chi square test was used to compare history of smoking, history of hypertension, history of diabetes, gender, and HP positive rate. The correlation between HP infection and clinical indicators was analyzed by linear correlation analysis. Results BMI, history of hypertension, history of diabetes, history of smoking, Fg, TG, TC, HDL-C, LDL-C, VLDL-C, HCY, and hs-CRP were significantly different between the CHD group and non CHD group. LBP, HP content, and the positive rate of HP was significantly higher in the CHD group than in the non-CHD group [(66.58±44.60) μg/L vs (44.27±18.78) μg/L, (192.71±102.19) ng/L vs (87.97±51.45) ng/L, 57.65% vs 12.90%; t=3.784, 7.258, χ2=18.327; P<0.05]. In patients with CHD, serum LBP in the HP positive group was significantly higher than that in the HP negative group [(90.49±45.79) μg/L vs (34.05±3.13) μg/L, t=8.601, P<0.05]. There was also a significant difference in TC between the HP positive group and HP negative group. HP content was positively correlated with BMI, Fg, TG, TC, LDL-C, VLDL-C, HCY, hs-CRP, and LBP (r=0.557, 0.648, 0.571, 0.696, 0.576, 0.468, 0.412, 0.470, and 0.872, respectively, P<0.001), and negatively correlated with HDL-C (r=-0.363, P<0.001). Conclusion HP infection is associated with CHD, and serum LBP level in HP infected CHD patients is high. Key words: Coronary heart disease; Helicobacter pylori; Lipopolysaccharide binding protein