Psoriasis: an example of the complexity of decision-making.

Until the early 2000s, treatment options for moderate-to-severe psoriasis were limited to a few systemic therapies, PUVA, and Narrowband-UVB. Since then, insights about the pathogenesis of psoriasis have led to the development of cytokine-based therapies which have revolutionized psoriasis management. However, with more than a dozen targeted therapies approved for psoriasis, keeping pace with the fast-growing repertoire of therapies and synthesizing the literature has become a more complex task.