Clinical research on the effect of hyperbaric oxygen for insulin resistance in diabetes complicated with acute cerebral infarction

Objective To observe the clinical efficacy of hyperbaric oxygen (HBO) in treatment of diabetes complicated with acute cerebral infarction (ACI) and its effect on insulin resistance (IR).Methods One hundred and twenty-eight patients with diabetes complicated with ACI were divided into control group and treatment group with 64 cases each by table of random digit.The control group was treated with routine medication,while the treatment group was treated with HBO besides routine medication.The two groups were treated for 14 days.The neural function defect degree score,fasting blood glucose (FPG),fasting insulin (FINS) and insulin action index (IAI) were assessed before and after treatment in each group.Correlation between the difference value of IAI and neural function defect degree score was analyzed with Pearson correlation analysis.Results The total effective rates in treatment group and control group were 87.50％ (56/64) and 70.31％(45/64) respectively,with a significant difference between two groups (P＜ 0.05).IAI after treatment in control group and treatment group showed significant difference compared with that before treatment (P＜ 0.05 or ＜ 0.01 ),but IAI after treatment in treatment group and control group had significant difference (-4.03 ± 0.51 vs.-4.22 ± 0.55,P ＜ 0.05).There was negative correlation between the difference value of IAI and neural function defect degree score (r =-0.696,P ＜ 0.01 ).Conclusion HBO may increase the clinical efficacy in treatment of diabetes complicated with ACI,and also it improves IR significantly. Key words: Diabetes mellitus;  Brain infarction ;  Hyperbaric oxygenation;  Insulin resistance