Deep learning enabled ultra-fast-pitch acquisition in clinical X-ray computed tomography.

OBJECTIVE In X-raycomputed tomography (CT), many important clinical applications may benefit from a fast acquisition speed. The helical scan is the most widely used acquisition mode in clinical CT, where a fast helical pitch can improve the acquisition speed. However, on a typical single-source helical CT (SSCT) system, the helical pitch p typically cannot exceed 1.5; otherwise, reconstruction artifacts will result from data insufficiency. The purpose of this work is to develop a deep convolutional neural network (CNN) to correct for artifacts caused by an ultra-fast pitch, which can enable faster acquisition speed than what is currently achievable. METHODS A customized CNN (denoted as ultra-fast-pitch network (UFP-net)) was developed to restore the underlying anatomical structure from the artifact-corrupted post-reconstruction data acquired from SSCT with ultra-fast pitch (i.e., p ≥ 2). UFP-net employed residual learning to capture the features of image artifacts. UFP-net further deployed in-house-customized functional blocks with spatial-domain local operators and frequency-domain non-local operators, to explore multi-scale feature representation. Images of contrast-enhanced patient exams (n = 83) with routine pitch setting (i.e., p   0.98) with lower mean rRMSE (  9.1%). Quantitative metrics at p = 3: UFP-net-mean SSIM [0.86, 0.94] and mean rRMSE [5.0%, 8.2%]; FBP-mean SSIM [0.36, 0.61] and mean rRMSE [36.0%, 58.6%]. CONCLUSION The proposed UFP-net has the potential to enable ultra-fast data acquisition in clinical CT without sacrificing image quality. This method has demonstrated reasonable generalizability over different body parts when the corresponding CT exams involved consistent base scan parameters.