Neurologic injury in patients treated with extracorporeal membrane oxygenation for postcardiotomy cardiogenic shock

Abstract Objective To investigate the frequency, predictors, and outcomes of neurologic injury in adults treated with postcardiotomy extracorporeal membrane oxygenation (PC-ECMO). Design A retrospective multicenter registry study. Setting Twenty-one European institutions where cardiac surgery is performed. Participants A total of 781 adult patients who required PC-ECMO during 2010-2018 were divided into patients with neurologic injury (NI) and patients without neurologic injury (NNI). Measurements and Main Results Baseline and operative data, in-hospital outcomes, and long-term survival were compared between the NI and the NNI group. Predictors of neurologic injury were identified. A subgroup analysis according to the type of neurologic injury was performed. Overall, NI occurred in 19% of patients in the overall series, but the proportion of patients with NI ranged from 0% to 65% between the centers. Ischemic stroke occurred in 84 patients and hemorrhagic stroke in 47 patients. Emergency procedure was the sole independent predictor of NI. In-hospital mortality was higher in the NI group than in the NNI group (79% vs. 61%, p Conclusion Neurologic injury during PC-ECMO is common and associated with dismal prognosis. There is considerable inter-institutional variation in the proportion of neurologic injury in PC-ECMO-treated adults. Well-known risk factors for stroke are not associated with neurologic injury in this setting.