Enantioselective Synthesis of the Lactone Moiety of HMG-CoA Reductase Inhibitor: Stereoselective Synthesis of (+)-(4R,6R)-4-Hydroxy-6-(2- phenylethyl)-tetrahydro-2H-pyran-2-one.

Abstract The enantioselective synthesis of the lactone moiety of (+)-compactin and (+)-mevinolin was established starting from a meso -3,5-dihydroxycyclohexanone derivative by employing an enantioselective deprotonation strategy.