Photodynamic therapy and nuclear imaging activities of SubPhthalocyanine integrated TiO2 nanoparticles

Abstract In this study, Subphthalocyanine (SubPc) and SubPc integrated TiO 2 nanoparticles (SubPc- TiO 2 ) were examined as theranostic agents. In vitro photodynamic therapy (PDT) efficiency of SubPc/SubPc-TiO 2 and nuclear imaging potential of 131 I labeled SubPc/TiO 2 -SubPc were determined on hepatocellular carcinoma (HepG2), colorectal adenocarcinoma (HT29) and human healthy lung (WI38) cell lines. As a result, 131I -SubPc and 131 I-SubPc-TiO 2 have been identified as a nuclear imaging agent for liver cancer. Additionally, 131 I-SubPc-TiO 2 has been found to be promising for imaging colon tumors. According to the in vitro photodynamic therapy studies, SubPc and SubPc-TiO 2 were determined suitable PDT agents for liver and colon tumors. These results suggest that SubPc-TiO 2 might be a theranostic agent with both PDT and nuclear imaging potential.