Common genetic variations of the renin-angiotensin-aldosterone system and response to acute angiotensin I-converting enzyme inhibition in essential hypertension

ObjectiveIn order to get insight into possible genetic determinants of antihypertensive drug action, we analysed the relations between polymorphisms of the genes of the renin–angiotensin–aldosterone system and acute effects of ACE inhibition on blood pressure as well as circulating renin and aldoste