Challenges in Liver Transplantation.

perimental therapeutic approach in the 20th century to a standard therapy in today's high-care medicine. In the realm of liver trans - plantation, there are still many highly relevant aspects in the field of translation of knowledge from basics to clinics not only in the pre-transplantation scenario but also during the evaluation pro - cess, indication, and intra- and postoperative management, espe- cially given that the number of donors does not comply with the demand of organs needed, which results in long waiting times. However, not all recipients survive until an organ becomes availa - ble and the mortality among patients on the waiting list remains high. Beside the need for recent and ongoing research focusing on the improvement of transplantation procedures, a lot of additional general issues related to transplantation problems have been the focus of debate, including clinical implications, regulations and limitations, and even gender mainstreaming. Therefore, the articles of this special issue focus on different as