Investigation of the Antiviral effect of Acyclovir on Canine Parvovirus Infection

The aim of the present study was to evaluate the Acyclovir as antiviral agent in prophylactic treatment of puppies experimentally infected by canine parvovirus 2. Fifteen apparently healthy native puppies less than 9 wks. old were grouped into 3 groups, each containing 5 puppies. These puppies were found to be free from CPV antibodies. The 1st group was prophylactly treated with Acyclovir; the 2nd group was kept infected without treatment, while the 3rd group was kept without infection and without treatment as control. Blood samples and fecal samples were collected at 0 day and daily up to 5th day post infection from all groups. Our results indicated that The Acyclovir regime was succeeded in prevention of CPV2 replication in puppies through absences of viral particles in fecal swabs.