Microelectroscope: a multimodal approach for morphological and functional recording of embryonic Zebrafish heart activity

In this paper we report the development of the Micro-electroscope, a multimodal approach that allows the recording of morphological evolution occurring within the developing heart of zebrafish embryos, while simultaneously recording its functional counterpart: in vivo non-invasive heart electrical activity. The system is based on both a custom made bright field microscope aiming to gather morphological imaging and a built-in chamber containing a novel Electric Potential Sensing (EPS) microelectrode to record the heart functional activity.