Studies on Pentenomycins. IV. Preparation and Antimicrobial Activities of Pentenomycin Derivatives

Eleven acyl and alkyliden derivatives of pentenomycin I (I) were synthesized for obtaining an improved antibiotic. All derivatives synthesized showed same order of or improved antimicrobial activity than the natural antibiotic. Among these derivatives, 2-bromo-4, 5, 6-triacetylpentenomycin I (XIV) showed strongest antimicrobial activity.