Establishing a Link Between Amino Acid Sequences and Self-Associating and Viscoelastic Behavior of Two Closely Related Monoclonal Antibodies

Sandeep Yadav,Alavattam Sreedhara,Sonoko Kanai,Jun Liu,Samantha Lien,Henry B. Lowman,Devendra S. Kalonia,Steven J. Shire

Establishing a Link Between Amino Acid Sequences and Self-Associating and Viscoelastic Behavior of Two Closely Related Monoclonal Antibodies

2011

Sandeep Yadav
Alavattam Sreedhara
Sonoko Kanai
Jun Liu
Samantha Lien
Henry B. Lowman
Devendra S. Kalonia
Steven J. Shire

Purpose To investigate the underlying cause for the observed differences in self-associating and viscoelastic behavior between two monoclonal antibodies, MAb1, and MAb2.

Keywords:

Viscoelasticity
Peptide sequence
Amino acid
Intermolecular force
Monoclonal antibody
Chemistry
Biochemistry
Chromatography
pharmacology toxicology
self association

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