~(153)Gd attenuation corrected ~(99m)Tc-MIBI gated myocardial perfusion single photon emission tomography for the assessment of left ventricular function

Objective:To evaluate the attenuation corrected(AC) 99m Tc-MIBI gated myocardial perfusion single photon emission tomography(G-SPECT) for the assessment of left ventricular ejection fraction(LVEF).Methods:Total 69 patients probably with coronary artery disease were enrolled in this study.All of them underwent resting G-SPECT and two dimensional echocardiography(2-DE).Left ventricular ejection fraction(LVEF),left ventricular end-diastolic volume(EDV) and left ventricular end-systolic volume(ESV) were acquired from attenuation corrected and non-attenuation corrected(NC) 99m Tc-MIBI G-SPECT and 2-DE.T test and correlation analysis were used to compared the parameter of heart function.Results: ① EDV and ESV measured by AC and NC G-SPECT were(79.6 ± 33.4) ml and(87.4 ± 34.8) ml(P 0.01),and(33.8 ± 29.9) ml and(36.7 ± 31.9) ml(P 0.01).EDV and ESV measured by AC were positively correlated with EDV and ESV measured by NC(r EDV = 0.99,y = 1.04x + 4.73,P 0.01;r ESV = 0.99,y = 1.06x + 0.79,P 0.01).② LVEF determined by AC and NC G-SPECT were(60.3 ± 9.2)% and(60.8 ± 9.9)%.No statistical significance was observed between them.However,the positive correlation was found between them(r = 0.98,y = 1.02x-1.04,P 0.01).③ LVEF measured by 2-DE was(54.6 ± 8.9)%,which was markedly lower than them determined by AC and NC(P 0.01).There were positive correlation between them(r NC = 0.88,y = 0.91x + 10.81,P 0.01;r ESV = 0.81,y = 0.87x + 13.10,P 0.01).Conclusion:LVEF measured by AC G-SPECT,which is accurate and reliable,correlates well with LVEF determined by NC G-SPECT and 2-DE.