How the clinical dosage of bone cement biomechanically affects adjacent vertebrae

This study evaluated the biomechanical changes in the adjacent vertebrae under a physiological load (500 N) when the clinically relevant amount of bone cement was injected into fractured cadaver vertebral bodies. The embalmed cadaver thoracolumbar specimens in which each vertebral body (T12–L2) had a BMD of 0.05) with pre-fracture, while the strain of adjacent lower vertebral body was significantly higher than that before fracture (p 0.05); L1/2 vertebral strain after augmentation was significantly less than that after the fracture (p 0.05). PVP may therefore have partially reversed the abnormal strain state of adjacent vertebral bodies which was caused by fracture.