A benzopyrroloisoquinoline alkaloid from Ficus fistulosa

Abstract A new benzopyrroloisoquinoline alkaloid, fistulosine ( 1 ), was isolated from the stem-bark of Ficus fistulosa (Moraceae) collected in Singapore, along with three known phenanthroindolizidine alkaloids, (−)-13aα-antofine ( 2 ), (−)-14β-hydroxyantofine ( 3 ) and (−)-13aα-secoantofine ( 4 ). (−)-13aα-Antofine ( 2 ) accounted for the antifungal activity against Aspergillus fumigatus and Candida albicans originally observed in the crude alkaloid extract.