Bioorthogonal Correlative Light-Electron Microscopy of Mycobacterium tuberculosis in Macrophages Reveals the Effect of Antituberculosis Drugs on Subcellular Bacterial Distribution

Thomas Bakkum,Matthias T. Heemskerk,Erik Bos,Mirjam G.J.M. Groenewold,Nikolaos Oikonomeas-Koppasis,Kimberley V. Walburg,Suzanne C. van Veen,Martijn J.C. van der Lienden,Tyrza van Leeuwen,Mariëlle C. Haks,Tom H. M. Ottenhoff,Abraham J. Koster,Sander I. van Kasteren

Bioorthogonal Correlative Light-Electron Microscopy of Mycobacterium tuberculosis in Macrophages Reveals the Effect of Antituberculosis Drugs on Subcellular Bacterial Distribution

2020

Thomas Bakkum
Matthias T. Heemskerk
Erik Bos
Mirjam G.J.M. Groenewold
Nikolaos Oikonomeas-Koppasis
Kimberley V. Walburg
Suzanne C. van Veen
Martijn J.C. van der Lienden
Tyrza van Leeuwen
Mariëlle C. Haks
Tom H. M. Ottenhoff
Abraham J. Koster
Sander I. van Kasteren

Bioorthogonal correlative light-electron microscopy (B-CLEM) can give a detailed overview of multicomponent biological systems. It can provide information on the ultrastructural context of bioortho...

Keywords:

Biochemistry
Ultrastructure
Correlative
Microscopy
Mycobacterium tuberculosis
Bioorthogonal chemistry
Electron microscope
Chemistry

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