Normalizing hepcidin predicts TMPRSS6 mutation status in patients with chronic iron deficiency

TO THE EDITOR: Iron-refractory iron deficiency anemia (IRIDA) is characterized by congenital iron deficiency (ID) that is poorly responsive to oral iron treatment. Biallelic mutations in TMPRSS6 are found in most patients with IRIDA.[1][1] TMPRSS6 negatively regulates synthesis of the iron